Chemotherapy may be given in a variety of ways; Intravenously (IV) - into a vein is the most common, Intramuscularly (IM) -injection into a muscle, Orally -by mouth, Subcutaneously (SC) -injection under the skin, Intralesionally (IL) directly into a cancerous area, Intrathecally (IT) - into the fluid around the spine, or Topically -medication will be applied onto the skin.