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Osteosarcomas vary greatly in radiological and pathological features and therefore needs careful diagnosis to differentiate this from other bone tumors. Most are high grade intramedullary osteosarcomas, about 5% are low grade lesions, some are secondary osteosarcomas (for example those caused by radiation therapy).
These tumors typically express high levels of alpha-fetoprotein (AFP). Germ cell tumors are most common in children and young adults, there are different sub-types including endodermal tumors (mostly found in children), dysgerminoma, teratoma, and seminoma (young men). The most common location of these tumors are the ovaries (in females) or testicles (in males). However, they can also develop in other... Read More